Symptoms
Recognising symptoms early is critical for reducing the risk of intravascular haemolysis (IVH), thrombosis and organ damage.1
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Adverse Event Reporting

Please report any adverse events via your national reporting system. Adverse events can also be reported to Alexion, AstraZeneca Rare Disease by contacting: https://contactazmedical.astrazeneca.com/

Kulasekararaj AG, et al. The Importance of Terminal Complement Inhibition in Paroxysmal Nocturnal Hemoglobinuria. Therapeutic Advances in Hematology. 2022;13:20406207221091046. Sharma VR. Paroxysmal Nocturnal Hemoglobinuria: Pathogenesis, Testing, and Diagnosis. Clinical Advances in Hematology & Oncology. 2013 1-12. Nishimura J-I, et al. Clinical Course and Flow Cytometric Analysis of Paroxysmal Nocturnal Hemoglobinuria in the United States and Japan. Medicine (Baltimore). 2004;83:193–207.  Schrezenmeier H, et al. Baseline Characteristics and Disease Burden in Patients in the International Paroxysmal Nocturnal Hemoglobinuria Registry. Haematologica. 2014;99:922–929. Lee JW, et al. Avulizumab (ALXN1210) vs Eculizumab in Adult Patients with PNH Naive to Complement Inhibitors: the 301 Study. Blood. 2019;133(6):530–539. Hill A, et al. Effect of Eculizumab on Haemolysis-Associated Nitric Oxide Depletion, Dyspnoea, and Measures of Pulmonary Hypertension in Patients with Paroxysmal Nocturnal Haemoglobinuria. British Journal of Haematology. 2010;149(3):414–425. Hillmen P, et al. Long-term effect of the Complement Inhibitor Eculizumab on Kidney Function in Patients with Paroxysmal Nocturnal Hemoglobinuria. American Journal of Hematology. 2010;85:553–559. Schrezenmeier H, et al. Baseline Clinical Characteristics and Disease Burden in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Updated Analysis from the International PNH Registry. Annals of Hematology. 2020;99(7):1505–1514. Jang JH, et al. Predictive Factors of Mortality in Population of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Results from a Korean PNH Registry. Journal of Korean Medical Science. 2016;31(2):214–221. de Latour RP, et al. Paroxysmal Nocturnal Hemoglobinuria: Natural History of Disease Subcategories. Blood. 2008;112:3099–3106. Kokoris S L, et al. Renal involvement in paroxysmal nocturnal hemoglobinuria: an update on clinical features, pathophysiology and treatment. Hematology. 2018 8):558-566. Hill A.Paroxysmal nocturnal haemoglobinuria. Nature Reviews Disease Primers 2017. Hillmen P, et al. Effect of the Complement Inhibitor Eculizumab on Thromboembolism in Patients with Paroxysmal Nocturnal Hemoglobinuria. Blood. 2007;110(12):4123–4128.  advance I am a healthcare professional registered in the EU I am not a
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