ALP-based HPP calculator
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When interpretating laboratory test results for the diagnosis of hypophosphatasia (HPP), it is important to determine the lower limits of alkaline phosphatase (ALP) using age- and sex-specific reference intervals (RIs).1

You can calculate ALP RIs for children and adolescents using the tool below, which includes five major analytical platforms - Abbott, Beckman, Ortho, Roche and Siemens, developed by the Canadian Laboratory Initiative in Pediatric Reference Intervals (CALIPER).1
Diagnosis of HPP can be confirmed by persistently low ALP and one or more characteristic sign and symptom2-9
Signs and symptoms
ALP, alkaline phosphatase; HPP, hypophosphatasia; RI, reference interval.
Adeli K, et al. The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper. Crit Rev Clin Lab Sci. 2017;54(6):358–413. ARUP. Alkaline phosphatase isozymes, Serum or plasma. Available at: https://ltd.aruplab.com/Tests/Pub/0021020. Last accessed February 2024. Colantonio DA, et al. Closing the gaps in pediatric laboratory reference intervals: a CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012;58:854–868. Adeli K. Biochemical Marker Reference Values across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey. Clin Chem. 2015;61(8):1049–1062. Schumann G. IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C. Part 9: Reference procedure for the measurement of catalytic concentration of alkaline phosphatase. Clin Chem Lab Med. 2011;49(9):1439–1446. Quest Diagnostics. Alkaline phosphatase. Available at: https://testdirectory.questdiagnostics.com/test/test-detail/234/alkaline-phosphatase?cc=MASTER. Last accessed February 2024. Labcorp. Alkaline phosphatase. Available at: https://www.labcorp.com/tests/001107/alkaline-phosphatase. Last accessed February 2024. Bishop N. Transformative therapy in hypophosphatasia. Arch Dis Child. 2016;101(6):514–515. Rockman-Greenberg C. Hypophosphatasia. Pediatr Endocrinol Rev. 2013;10(Suppl 2):380–388.