The causes & risk factors of NMOSD

For EU Healthcare Professionals Only

Risk factors for NMOSD

AQP4+ NMOSD has also been associated with specific human leukocyte antigen (HLA) alleles, as well as other autoimmune disorders such as systemic lupus erythematosus.^1,2 Additional risk factors that have been suggested to play a role in NMOSD include smoking and infections.^1,2

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AQP4, aquaporin-4; HLA, human leukocyte antigen; IgG, immunoglobulin G; IL17A, interleukin 17A; NMOSD, neuromyelitis optica spectrum disorder.

Jarius S, et al. Neuromyelitis optica. Nat Rev Dis Primers. 2020;6(1):85.

Wingerchuk DM, Lucchinetti CF. Neuromyelitis optica spectrum disorder. N Engl J Med. 2022;387(7):631–639.

Weinshenker BG, Wingerchuk DM. Neuromyelitis spectrum disorders. Mayo Clin Proc. 2017;92(4):663–679.

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