HPP Matters This website has been designed to provide a source of general education around the condition hypophosphatasia (HPP).
HPP is an inherited, rare metabolic disorder that may affect multiple parts of the body. Organs and tissues such as the bones, muscles, teeth and nervous system can be affected. However, the disease affects each person differently and can change over time, leading to a wide range of symptoms.
There are many different signs and symptoms of HPP that may significantly impact a person's life. However, it can still be difficult to identify.

For more information on symptoms of HPP, click the link below.
Learn more about HPP

What does HPP look like in children?

Learn more about HPP in children

Common symptoms of HPP in children include premature loss of teeth (with the root intact), bone fractures, pain, bowing of the limbs, muscle weakness, and growth difficulties.

What does HPP look like in adults?

Learn more about HPP in adults

In adults, bone and muscle pain, mobility challenges, muscle weakness, and recurrent fractures are all signs of HPP.

The information provided in this material is intended as a source of education for the general public. It is not intended for any self-diagnosis purposes nor to replace the advice of your doctor or healthcare professional. Please consult your doctor or healthcare professional if you have any questions or concerns.