HPP diagnosis: from a radiological perspective

How can you spot the signs of hypophosphatasia (HPP) in radiographic images? Prof. Offiah, a paediatric radiologist from the United Kingdom, presents two case studies that highlight the key radiographic manifestations of HPP in infants. When observing atypical features of rickets or other bone demineralisation conditions, such as the absence of whole bone ossification or the presence of bone spurs and wide cranial sutures, Prof. Offiah asks physicians to think of and consider HPP as a differential diagnosis.¹

Offiah AC, et al. Pediatr Radiol. 2019;49(1):3–22.

Professor of Paediatric Musculoskeletal Imaging University of Sheffield and Sheffield Children's Hospital, Sheffield, UK

Prof. Amaka Offiah's undergraduate training took place in Nigeria. She obtained her Membership of the Royal Colleges of Physicians while working at Oldchurch Hospital, Essex, UK, and then trained as a radiologist in Sheffield, UK.

Prof. Offiah moved to London, UK, to Great Ormond Street Hospital, UK, and the Institute of Child Health, where she obtained a PhD for her thesis, “Optimisation of the digital radiographic imaging of suspected non-accidental injury”. Prof. Offiah then returned to Sheffield as a Higher Education Funding Council for England-funded Clinical Senior Lecturer in the Academic Unit of Child Health, was promoted to Reader in Paediatric Musculoskeletal Imaging in January 2015 and promoted to Chair in Paediatric Musculoskeletal Imaging in January 2020.

VIDEO HPP diagnosis: from an endocrinological perspective How do endocrinologists interpret metabolic parameters to support the diagnosis of hypophosphatasia (HPP)? This video discusses the challenges and strategies involved in diagnosing HPP from an endocrinologist's perspective.

VIDEO HPP diagnosis: from a neurological perspective What is the significance of neurological manifestations in the diagnosis and management of hypophosphatasia (HPP)? Dr Lampe, a paediatric neurologist from Germany, highlights how neurological symptoms in children and adults contribute to the overall clinical picture of HPP diagnosis.